Combining PT-141 and oxytocin in a nasal spray offers a convenient, rapid-acting, and potentially synergistic solution for potentially enhancing sexual arousal, desire, and emotional bonding and reducing anxiety.
PT-141 works by activating specific melanocortin receptors- namely, MC1R, MC3R, and MC4R- located in the hypothalamus, a brain region integral to sexual arousal. Research using PT-141 administration in rat models has shown that it helps stimulate these receptors to cause penile erections. This hypothalamic activation emphasizes the function of melanocortin receptors in controlling sexual responses and the therapeutic potential of PT-141 for treating sexual dysfunction.
Melanocortin receptors (MCRs) regulate sexual function, pigmentation, energy balance, and inflammation. These diverse functions make the MCR family a research focus. The melanocortin-4 receptor (MC4R) is essential to sexual function, as its activation can affect sexual arousal.
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